From Connectivity to Biomarker
Janine Bijsterbosch, Oxford University
Dysfunctional brain connectivity is associated with a large variety of neurological and psychiatric disorders and therefore promises to be an important biomarker for early detection, diagnosis, and optimized treatment in key patient populations. In order to develop connectivity markers that are of predictive value in individual patients, it is critically important to address a range of challenges linked to methodology, interpretation, and translation. In this talk I will describe how my research aims to address these challenges by carefully mapping and understanding different types of variability. I will discuss results from three studies to illustrate this approach: i) connectivity markers associated with variability in trait and induced anxiety, ii) within- and between-subject variability in BOLD amplitude, and iii) the role of spatial variability in driving functional connectivity. These results show the importance of bridging between advanced analysis methods and applied clinical neuroscience to identify and interpret clinically relevant connectivity markers. I will finish my talk by briefly summarizing my future research plans.