Information coding and calcium dynamics in hippocampal mossy fiber terminals
Katalin Tóth, PhD
Professor, CERVO Brain Research Centre, Université Laval
The major focus of our work is to understand how information is transferred between neurons. Granule cells are at the interface between cortical and hippocampal networks, cortical information is transformed to hippocampal code via the giant mossy fiber terminals. This synapse is strong enough to trigger postsynaptic firing, hence an ideal system to study the correlation between presynaptic and postsynaptic activity. We use electrophysiological approaches, presynaptic calcium measurements and experimentally-constrained modelling of neurotransmitter release to unveil the logic used by these synapses to translate presynaptic firing patterns to postsynaptic action potentials. We aim to identify the fundamental principles of presynaptic information processing and addresses the fine-scale elements that supporting this function.
Short-Term Facilitation at a Detonator Synapse Requires the Distinct Contribution of Multiple Types of Voltage-Gated Calcium Channels. Chamberland, Simon, Evstratova Alesya, and Tóth Katalin, J Neurosci, 2017 May 10, Volume 37, Issue 19, p.4913-4927, (2017)
Vesicles derived via AP-3-dependent recycling contribute to asynchronous release and influence information transfer. Evstratova, Alesya, Chamberland Simon, Faundez Victor, and Tóth Katalin , Nat Commun, 2014 Nov 20, Volume 5, p.5530, (2014)
Host: Ivan Soltesz, PhD & Michael Lin, MD PhD