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Competitive vasodynamics in cortex and what it informs us about neuronal activity
Abstract
I first review the murine brain vascular connectome, with a focus on connecting local vascular geometry to brain metabolic load. I then segue to past and ongoing experiments on the dynamics of the pial arteriole network, which distributes blood across the cortical mantle to source nourishment to brain cells. Far from a passive network, the diameter of pial and penetrating arterioles intrinsically oscillate in the ~ 0.1 Hz vasomotor band to produce spatial patterns of coherent oscillations. These patterns depend on the competition between local vasomotor oscillators and underlying neuronal excitations in the vasomotor band. I conclude with a discussion on the inference of neuronal processes from optical and fMRI measurements of vasodynamics.
David Kleinfeld, PhD
University of California, San Diego
David Kleinfeld is a Distinguished Professor at UC San Diego. He received his Ph.D. in Physics in 1984 and then spent a decade working at the former AT&T Bell Laboratories, where his research shifted to neuroscience. He joined the Physics faculty at UC San Diego in 1996 and gained affiliate appointments in Neurobiology and at the Salk Institute. David leads a diverse, multi-disciplinary laboratory that delimits circuits in the brain. One class are neural circuits that underlie active sensing, with a focus on orofacial behaviors. The second class are neurovascular circuits that underlie the control of blood flow, with a focus on cortical vasodynamics. David's approach is guided by engineering and physical principles and involves instrument design and mathematical modeling as needed.
Hosted by - Xiaoke Chen (Xiaoke Chen Lab, view host profile below)
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About the Wu Tsai Neurosciences Seminar Series
The Wu Tsai Neurosciences Institute seminar series brings together the Stanford neuroscience community to discuss cutting-edge, cross-disciplinary brain research, from biochemistry to behavior and beyond.
Topics include new discoveries in fundamental neurobiology; advances in human and translational neuroscience; insights from computational and theoretical neuroscience; and the development of novel research technologies and neuro-engineering breakthroughs.
Unless otherwise noted, seminars are held Thursdays at 12:00 noon PT.
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