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Photovoltaic epiretinal prosthesis restores high-resolution responses in blind retinas -- Diego Ghezzi

March 30, 2021 - 12:00pm

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Diego Ghezzi, Ph.D.

Ecole Polytechnique Fédérale de Lausanne, Switzerland

Abstract:

Retinal prostheses hold the promise of restoring vision in totally blind people. However, a decade of clinical trials highlighted quantitative limitations hampering the possibility of reaching this goal. A key challenge in retinal stimulation is to independently activate retinal

neurons over a large portion of the subject’s visual field. Reaching such a goal would significantly improve the perception accuracy in retinal implants’ users, along with their spatial cognition, attention, ambient mapping and interaction with the environment. Here we show a wide-field, high-density and high-resolution photovoltaic epiretinal prosthesis for artificial vision (POLYRETINA). The prosthesis embeds 10,498 physically and functionally independent photovoltaic pixels, allowing for wide retinal coverage and high-resolution stimulation.

Single-pixel illumination reproducibly induced network-mediated responses from retinal ganglion cells at safe irradiance levels. Furthermore, POLYRETINA allowed response discrimination with a high spatial resolution equivalent to the pixel pitch (120 μm) thanks to the network-mediated stimulation mechanism. This approach could allow mid-peripheral artificial vision in patients with retinitis pigmentosa.

 

https://www.nature.com/articles/s43246-021-00133-2

 

Bio: https://people.epfl.ch/diego.ghezzi

Event Sponsor: 
Hansen Experimental Physics Laboratory