Professor of Neuroscience and Neurotechnology
Swiss Federal Institute of Technology, Lausanne (EPFL)
With students Barraud Quentin, Claudia Kathe, Hutson Thomas Haynes, Ismael Seáñez, Simon Borgognon, Macellari Nicolò, Léonie Asboth and Lorach Henri
Spinal cord injury alters the communication between the brain and spinal cord, leading to unrecoverable neurological deficits, including the partial of complete loss of movement. We have Identified the afferent gateways that enable epidural electrical stimulation to access circuits embedded in the spinal cord. This understanding translated into neuromodulation technologies that target these afferent gateways to restore motor functions. Combined with rehabilitative training, these targeted neuromodulation strategies restored walking and improved neurological recovery in people with spinal cord injury; but the number of addressable functions with these neurotechnologies is growing.
Targeted neurotechnology restores walking in humans with spinal cord injury. Wagner FB, Mignardot JB, Le Goff-Mignardot CG, Demesmaeker R, Komi S, Capogrosso M, Rowald A, Seáñez I, Caban M, Pirondini E, Vat M, McCracken L, Heimgartner R, Fodor I, Watrin A, Seguin P, Paoles E, Van Den Keybus K, Eberle G, Schurch B, Pralong E, Becce F, Prior J, Buse N, Buschman R, Neufeld E, Kuster N, Carda S, von Zitzewitz J, Delattre V, Denison T, Lambert H, Minassian K*, Bloch J* and Courtine G*. Nature. 2018. 563(7729-65-71).
2. A brain-spine interface alleviating gait deficits after spinal cord injury in primates. Capogrosso M, Milekovic T, Borton D, Wagner F, Moraud EM, Mignardot JB, Buse N, Gandar J, Barraud Q, Xing D, Rey E, Duis S, Jianzhong Y, Ko WK, Li Q, Detemple P, Denison T, Micera S, Bezard E, Bloch J, Courtine G. Nature. 2016 Nov 10;539(7628):284-288. doi: 10.1038/nature20118. PMID: 27830790
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