National Institute of Mental Health
Background: Chemical modifications of proteins, DNA and RNA nucleoside moieties play a crucial role in gene regulation. The role of chemical modifications of RNA molecules (the epitranscriptome) in mediating brain functions is relatively unexplored. A few covalent RNA modifications have been studied extensively, and recent evidence suggests that other newly discovered RNA modifications have interesting biological and disease functions in mammals.
Standard R01 deadlines: Feb. 5, June 5 Oct. 5