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About the Knight Initiative

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The Knight Initiative for Brain Resilience envisions a world in which our brains remain fit and healthy as we age.

We are harnessing the collective genius of science and breaking free of established dogma to extend the healthy lifespan of the human brain — building the foundations for a world in which the word “dementia” is forgotten.

We are:

  • Pursuing bold, untried approaches to advance the science of brain aging and resilience

  • Sharing data, technologies, and know-how to drive progress across the field

  • Linking fundamental research, human neuroscience, and clinical applications to accelerate the science of brain resilience and our impact on patients

  • Achieving together what none of us can accomplish alone


We welcome scientists of all stripes, from pathologists to data scientists and beyond, to join our growing, interdisciplinary community focused on the science of resilient brain aging.

Read more about the launch of the Knight Initiative

“This initiative will examine long-standing assumptions about the causes of neurodegeneration and advance our understanding of how to maintain brain resilience into old age, which is a cornerstone of quality of life.”

 Stanford President Marc Tessier-Lavigne

“We are calling it the ‘Initiative for Brain Resilience’ because we want to focus on the positive outcomes this important research may yield—healthy aging and the possibility of helping all people live fuller, more vibrant lives late into life. We are excited to invest behind our belief that Stanford is the place to make this happen, and we feel privileged to have the opportunity to do so.”

 Penny Knight

"About one in ten thousand individuals reaches age 100 cognitively unscathed—seemingly resilient to the effects of time. The Phil and Penny Knight Initiative for Brain Resilience seeks to emulate this sidestepping of the aging process and raise the hope of reversing brain aging altogether to rejuvenate the mind.

— Tony Wyss-Coray, Knight Initiative Director

Contact Knight Initiative for Brain Resilience

Knight Initiative for Brain Resilience
Stanford Neurosciences Building
290 Jane Stanford Way, Rm E152
Stanford, CA 94305

Connect with Knight Initiative for Brain Resilience