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Funded Research Projects

NeuroDiscovery | Seed Grant
Lead Researcher(s): Alexander Dunn, Thomas Sudhof
The results of this highly interdisciplinary project will test the innovative hypothesis that molecular-scale mechanical signals sculpt synapse formation and will shed light on how latrophilin signaling regulates synaptogenesis in the context of both neurodevelopment and neuropsychiatric disease.
NeuroHealth | Seed Grant
Lead Researcher(s): Carla Shatz, Anca M. Pasca, MD
Maternal infection is linked to increased risk of neurodevelopmental disorders such as autism and schizophrenia. This proposal examines how virus-associated cytokines, specifically interferons, affect human neurons modeled in brain organoids or studied directly in fetal brain samples.
NeuroEngineering | Seed Grant
We propose a new magnetic sensor that is sensitive to picoTesla-scale fields, a localized magnetic stimulator with small form-factor, and a seamless integration of both systems for applications in experimental and clinical neuroscience.
NeuroHealth | Seed Grant
Lead Researcher(s): Xinnan Wang, Michael Bassik
We will comprehensively define the gene network associated with mitochondrial dysfunction in Parkinson's disease using a cutting-edge technology, CRISPR, to understand how these nerve cells die in PD and how we can reverse the cell death to treat the disease.
NeuroEngineering | Seed Grant
Lead Researcher(s): Guosong Hong, Xiaoke Chen
We aim to develop a noninvasive method to produce on-demand and dynamically programmable light emission patterns throughout the entire brain of live mice. The emission patterns can be controlled by brain-penetrant focused ultrasound and switched with millisecond precision for rapid brain-wide...
NeuroDiscovery | Seed Grant
These tools will enable us to dissect how myelin contributes to specific brain circuits and types of neurons, bringing us closer to a holistic understanding of how cells in the brain collaborate to build a functional nervous system.
NeuroEngineering | Seed Grant
We believe our research has the potential of generating transformative results for both neuroscience research and neurological applications, also offering strategies to manipulate key intracellular pathways to prevent gliosis in therapeutic neural implants.
NeuroHealth | Seed Grant
Lead Researcher(s): David Kingsley, Jennifer L. Raymond
We will combine the genetics expertise of the Kingsley lab and the neuroscience expertise of the Raymond lab to characterize molecular, cellular, neurophysiological, and behavioral defects in mice engineered to model the risk or protective variants in the human calcium channel gene.
NeuroHealth | Seed Grant
This proposal brings together faculty with this diverse expertise to develop the first gold standard test of auditory-vocal affect. Once developed, validated, and normed, we will deploy this test in the clinical context of autism to quantify impairments and direct neurobiological investigation.
NeuroHealth | Seed Grant
This team will leverage the power of silicon probes to record from hundreds of neurons in mouse epilepsy models to understand neural correlates of the pre-seizure EEG. These results will be used to optimize a real-time seizure prediction algorithm that will be tested in human patients.

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