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Alzheimer's Disease Models

T41B (Thy1-hAPPLond/Swe+ [Line 41])

T41B (Thy1-hAPPLond/Swe+ [Line 41])

T41b transgenic mice show mature amyloid-beta plaques, pathological hallmarks of AD, in the frontal cortex as early as 3-4 months of age and develop plaques in the hippocampus, thalamus, olfactory region, basolateral amygdala, and subiculum at the age of 5-7 months.


PS19

PS19 (B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J)

PS19 transgenic mice express the P301S mutant form of human tau and develop progressive accumulation of neurofibrillary tangles with age.  Thus, the strain is commonly used as a model of tauopathy, such as Alzheimer's Disease.


5XFAD

Coming soon...


Taconic APPSWE

Coming soon...