Ts65Dn mice are the most commonly used mouse model of Down Syndrome (DS).
This mouse is generated by Robertsonian segmental translocation of mouse chromosome 16 (MMU16) to the MMU17 centromere. This chromosomal segment contains an extra copy of more than 100 gene homologues to HSA21. Ts65Dn mice have shorter life expectancies and show morphological, neurological, and structural abnormalities that parallel those found in patients with DS.
They show changes in the structure and function of neuronal circuits, including deficits in hippocampal synaptic plasticity. These changes have been demonstrated in both cellular signaling and electrophysiological studies. Ts65Dn mice also display behavioral abnormalities similar to those seen in DS.