Interactions between nervous and vascular systems in the CNS
Professor of Neurobiology
Harvard Medical School
My laboratory studies the interface of the nervous and vascular systems. Proper brain function depends on two unique features of the brain vasculature. First, brain blood vessels form the blood-brain barrier (BBB), which maintains the brain’s chemical milieu and ensures proper neural function. Second, neural activity rapidly increases local blood flow to meet moment-to-moment changes in regional brain energy demand – a process called neurovascular coupling. I will share with you our current and future work to understand the molecular and cellular mechanisms underlying BBB and neurovascular coupling.