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SLM-based methods for 3D control and imaging in the brain - Darcy Peterka

Wu Tsai Neurosciences Institue, seminar series
December 5, 2019 - 12:00pm to 1:00pm
Clark Center Auditorium

Darcy Peterka

Darcy Peterka, PhD 

Senior Scientist and Director of Cellular Imaging in the Zuckerman
Mind Brain Behavior Institute and Director of Technologies,
NeuroTechnology Center,
Columbia University

Host: Jun Ding


Recording neuronal activity throughout the brain with high temporal and spatial resolution may be a critical step in understanding how the brain works. Task-based approaches allow intelligent trade-offs between resolution, speed, and signal. I will describe projective two-photon imaging methods that leverage the spatiotemperal sparseness of neural activity and use holographic multiplexing, and statistical source separation create capable platforms for high-performance imaging with single cell resolution. Similar holographic platforms can also be used to activate ensembles of neurons with single cell precision, and I will describe recent efforts to improve targeting and control in awake behaving animals

Curriculum vitae

Related paper

[1] Weijian Yang, Luis Carrillo-Reid, Yuki Bando, Darcy S Peterka, & Rafael Yuste. Simultaneous two-photon imaging and two-photon optogenetics of cortical circuits in three dimensions. eLife 2018. 7: e32671. doi:10.7554/eLife.32671.001

[2] WeijianYang, Jae-eun, Kang Miller, Luis Carrillo-Reid, Eftychios Pnevmatikakis, Liam Paninski, Rafael Yuste, Darcy S.Peterka. Simultaneous Multi-plane Imaging of Neural Circuits. Neuron. 2016 Jan 20;89(2):269-84. doi: 10.1016/j.neuron.2015.12.012

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Wu Tsai Neurosciences Institute
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