The processing and retention of sensory input is influenced by a number of endogenous factors, such as arousal, motivation, and cognitive control. These factors appear to constrain the sensory information guiding adaptive behavior. This lecture will discuss recent evidence on the neural circuits involved in the modulation, filtering and persistence of sensory information and their relation to basic cognitive functions such as attention and working-memory. Evidence from a range of model systems and approaches will be discussed, as well as relevance to mental disorders.
 Engel TA, Steinmetz NA, Gieselmann MA, Thiele A, Moore T, Boahen K. (2016). Selective modulation of cortical state during spatial attention. Science. 354(6316): 1140-1144. doi: 10.1126/science.aag1420.