Trans-ancestry GWAS of hot flashes reveals potent treatment target and overlap with psychiatric disorders

https://dx.doi.org/10.1038/s43856-025-01305-8
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Kathryn E Werwath, Rebecca B Lawn, Madeleine T Salem, Tayden Li, Brittany L Mitchell, Hanyang Shen, Scott D Gordon, Benson Kung, Ciera Stafford, Mytilee Vemuri, Andrew Ratanatharathorn, Joeri Meijsen, Aladdin H Shadyab, Charles Kooperberg, Karestan C Koenen, Carolyn J Crandall, Nicholas G Martin, Laramie E Duncan,
BACKGROUND: Most women experience hot flashes (hot flushes) during the menopause transition. Menopausal hot flashes typically persist for years, and for a sizeable minority of women, are substantially impairing. Genetic investigations can improve understanding of hot flash etiology.