Event Details:
Recruitment of cognitive reserve with central brain deep brain stimulation: clinical and experimental studies, rationale and evidence for underlying mechanisms
Nicholas Schiff, MD Professor of Neurology and Neuroscience, Brain and Mind Institute, Cornell University
Host: Jin Hyung Lee
Abstract
This presentation will provide a systematic review of the rationale for the use of central thalamic deep brain stimulation (CT-DBS) to support impaired cognitive function following non-progressive brain injuries. New clinical and experimental findings will be shown and explained in the context of prior studies in both animal models and a pilot clinical trial. The role of the anterior forebrain mesocircuit in impaired cognitive function following multi-focal brain injuries will be discussed in the context of model predictions and the testing of these predictions in human subject studies. The presentation will outline the mechanistic continuity of the proposed role for CT-DBS across a range of clinical outcomes aimed at restoring activity within the anterior forebrain mesocircuit.