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A strategy for identifying loss of function mutations that slow photoreceptor degeneration in vivo - Douglas Vollrath

Douglas Vollrath, Stanford Neurosciences Institute
October 31, 2017 - 11:35am to 12:05pm
James H. Clark Auditorium

A strategy for identifying loss of function mutations that slow photoreceptor degeneration in vivo

Douglas Vollrath

Associate Professor of Genetics

2015 Seed Grant: In vivo selection for gene mutations that counteract photoreceptor degeneration

Lead Researchers: Douglas VollrathMichael BassikMonte Winslow

Abstract

Mendelian forms of photoreceptor degeneration arise from mutation of any one of hundreds of different genes. We hypothesize that these diverse proximate causes converge on a limited number of deleterious cellular pathways. If so, interdicting one or more of these pathways could provide a more general approach to slowing photoreceptor degeneration, as compared to therapies aimed at replacement of individual defective genes. We have devised a strategy to identify loss of function mutations that slow photoreceptor degeneration in a mouse model of retinitis pigmentosa. We will report our progress toward achieving the goal of performing a global screen in live mice.

Event Sponsor: 
Stanford Neurosciences Institute
Contact Email: 
neuroscience@stanford.edu
Contact Phone: 
650-723-3573

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