Knight Initiative News

In this research roundup, we look back on some of the ways Knight Initiative scientists have been pursuing ways to keep our minds sharp well into old age

The teams will tackle questions linked to Parkinson's pathology and mechanisms with an eye toward treatments

Amyloid plaques have long been the focus of Alzheimer’s therapies. But Wu Tsai Neuro's Emmanuel Mignot and others are focusing on the stringy tangles of a protein called tau, the unsung second hallmark of Alzheimer’s.

Knight Initiative researchers used a new lab model of aging human neurons to show that as cells age, lysosomes fall into disrepair and waste builds up—feeding a damaging cycle that could lead to Alzheimer’s.

Is your brain aging faster than your chronological age? New research shows it could raise your risk of death and dementia significantly—and offers promise for early intervention.