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Brain Plasticity’s Dark Side: New Insights into Addiction Mechanisms

Wu Tsai Neuro affiliate Michelle Monje and team discovered that adaptive myelination, a form of brain plasticity, contributes to drug addiction. A single morphine dose in mice triggered myelination in reward-related brain circuits, reinforcing drug-seeking behavior. Blocking this myelination prevented addiction, highlighting potential new treatment strategies.
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Image of a brain scan