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Map the circuits

If you wanted to reverse-engineer a piece of electronics, the first thing you'd investigate is how the various parts are connected. In the brain, that means tracing the paths of 100 billion neurons.
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Manipulate the signals

When people are confronted with an unknown piece of electronics, one way they can figure out how it works and what it does is to twiddle with the knobs and switches. That's been hard to do with the slick, knob-less surface of the brain.
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