Effects of α-synuclein pathology on synaptic dysfunction and clinical outcomes in normal aging

Alzheimer's & Dementia
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Joseph R Winer, Melanie J Plastini, America Romero, Hillary Vossler, Isha Sai, Divya Channappa, Carla Abdelnour, Marian Shahid-Besanti, Edward N Wilson, Hamilton Se-Hwee Oh, Christina B Young, Alexandra Trelle, Maya Yutsis, Sharon J Sha, Veronica Ramirez, Ryan Taylor, Kyan Younes, Tony Wyss-Coray, Michael D Greicius, Victor W Henderson, Anthony D Wagner, Kathleen L Poston, Elizabeth C Mormino
INTRODUCTION: α-Synuclein is the hallmark pathology of Parkinson's disease and dementia with Lewy bodies, described together as Lewy body disease (LBD). We investigated effects of α-syn biomarker positivity in clinically unimpaired (CU) individuals.