Cigarette smoking, history of major depression and PTSD diagnosis are associated with metabolite levels in the left dorsolateral prefrontal cortex in those in treatment for alcohol use disorder

Drug and Alcohol Dependence
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Timothy C Durazzo, Riley E Carolan, Lauren H Beauregard, Meng Gu, Claudia B Padula
BACKGROUND: Despite the known systemic health risks associated with cigarette smoking, research investigating the neurobiological consequences of smoking in those with alcohol use disorder (AUD) is minimal. This study compared metabolite levels in the left dorsolateral prefrontal cortex (DLPFC) in non-cigarette smoking individuals, former cigarette smoking individuals and active cigarette smoking individuals who were Veterans in residential treatment for AUD.