High resolution, contrast-enhanced X-ray microscopy of the <em>ex vivo</em> human cochlea: technical feasibility and biometric case analysis

Frontiers in Neuroscience
 |
Sophie S Jang, Charvi Malhotra, Stephen McInturff, Shelley Batts, Konstantina M Stankovic
BACKGROUND: The human cochlea is a fragile, spiral-shaped sensory organ for hearing that is deeply embedded within the dense otic capsule bone, making accurate post-mortem anatomical studies difficult when using conventional histological approaches requiring sectioning. X-ray microscopy (XRM) is a non-destructive radiological imaging modality that combines geometric and optical magnification to achieve high-resolution 3D visualization.