A major goal in systems neuroscience is to discover how patterns of activity in neural circuits produce and regulate behavior. Using synthetic biology tools, this team aims to develop first-in-class genetically encoded voltage integrators (GEVIns) capable of sensing and responding to both activation and inhibition of neurons.
The goal is to forge an inter-disciplinary collaboration between physicists, biologists, chemists, and translational medical scientists by inventing new ways of visualizing the brain, from individual molecules to neuronal circuits to entire brain regions, from a normally functioning neuron to a diseased brain.
We propose to connect diverse faculty to deepen interdisciplinary understanding of the neural mechanisms supporting addictive choice by combining conceptual, experimental, and clinical approaches that bridge historically disparate fields of inquiry.
