Brain Resilience Special Seminar: Marco Prinz

Event Details:

Monday, March 3, 2025
This Event Has Passed
Time
10:00am to 11:00am PST
Contacts
brainresilience@stanford.edu
Event Sponsor
Knight Initiative for Brain Resilience, Wu Tsai Neurosciences Institute
Add to calendar:
Image
Banner image featuring one rectangle headshot against a purple and blue background design

The Knight Initiative for Brain Resilience will host a special seminar to bring together awardees, affiliated professors and students for a series of 'lab meeting' styled talks. One speaker will discuss their brain resilience research, experience in the field, and answer questions about their work.

To support our researcher's participation in this open science ‘lab-meeting style’ exchange of ideas, these seminars are not streamed/recorded and are only open to members of the Stanford community. 

Marco Prinz, University of Freiburg, Germany

Hosted by Tony Wyss-Coray

The myeloid side of the brain

The innate immune compartment of the human central nervous system (CNS) is highly diverse and includes several immune-cell populations such as macrophages that are frequent in the brain parenchyma (microglia) and less numerous at the brain interfaces as CNS-associated macrophages (CAMs). Due to their scantiness and particular location, little is known about the presence of temporally and spatially restricted CAM subclasses during development, health and perturbation. Here we combined single-cell RNA sequencing, time-of-flight mass cytometry and single-cell spatial transcriptomics with fate mapping and advanced immunohistochemistry to comprehensively characterize the immune system at human CNS interfaces with over 356,000 analyzed transcriptomes from 102 individuals. We also provide a comprehensive analysis of resident and engrafted myeloid cells in the brains of 15 individuals with peripheral blood stem cell transplantation, revealing compartment-specific engraftment rates across different CNS interfaces. Integrated multiomic and high-resolution spatial transcriptome analysis of anatomically dissected glioblastoma samples shows regionally distinct myeloid cell-type distributions driven by hypoxia. Notably, the glioblastoma-associated hypoxia response was distinct from the physiological hypoxia response in fetal microglia and CAMs. Our results highlight myeloid diversity at the interfaces of the human CNS with the periphery and provide insights into the complexities of the human brain's immune system.

 

Image
Banner image featuring one circle headshot against a purple and blue background design

 

Click here to download the event poster