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Circuit mechanisms underlying sensori-motor integration in mouse - Tianyi Mao

November 12, 2015 - 12:00pm to 1:00pm
Clark Center Auditorium

Stanford Neurosciences Institute Seminar Series Presents

 

Circuit mechanisms underlying sensori-motor integration in mouse

 

 

Tianyi Mao, Ph.D

 

 

Assistant Scientist, Oregon Health Sciencese University

 

Host: Aaron Gitler

Abstract

My laboratory is interested in elucidating the circuit mechanisms governing the sensori-motor integration. Specifically, the topic I will cover is to examine the principles governing the neuronal connectivity among the cortex, the thalamus and the striatum, which are essential brain regions for motor control and sensory-motor integration, by using quantitative anatomy, imaging and functional circuit analyses in mouse.  Based on high resolution, high throughput tracing/imaging, we identified novel functional sub-regions in the thalamus and the striatum based on their input/output connectivity and I will discuss some parallel circuitry organization principles of the cortico-thalamo-basal ganglia circuits.  With the ability to pinpoint the anatomically defined sub-regions, we also uncovered cell type heterogeneity based on quantification of sub-region specific inputs among otherwise homogeneous cell population. The cell type specific and sub-region specific mapping might shed new light on how the cortico-thalamo-basal ganglia circuits achieve their functions. 

Recent Papers:

[1] A comprehensive thalamocortical projection map at the mesoscopic level Barbara J. Hunnicutt, Brian R. Long, Deniz Kusefoglu, Katrina J. Gertz, Haining Zhong, Tianyi Mao Nature. 2014 Aug 3;17:1276-85. doi:10.1038/nn.3780

[2] Long-rang neuronal circuits underlying the interaction between sensory and motor cortex Tianyi Mao, Deniz Kusefoglu, Bryan M. Hooks, Daniel Huber, Leopoldo Petreanu, Karel Svoboda Neuron. 2011 Oct 6;71:111-23. doi:10.1016/j.neuron.2011.07.029

Curriculum Vitae

Event Sponsor: 
Stanford Neurosciences Institute
Contact Email: 
neuroscience@stanford.edu
Contact Phone: 
650-497-8019

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