Daniel Gonzales - Circuit Mechanisms Underlying Sensory-Driven Traveling Waves

Event Details:

Tuesday, May 23, 2023
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11:00am to 12:00pm PDT
Event Sponsor
Wu Tsai Neurosciences Institute
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Circuit Mechanisms Underlying Sensory-Driven Traveling Waves

Abstract -  Traveling waves are a ubiquitous feature of neuronal activity. Both evoked  and spontaneous traveling waves across the spatiotemporal spectrum have been  implicated in a wide range of cognitive functions, including sensory processing, motor  control, and working memory. As these waves propagate across a cortical region, they  coordinate local activity by influencing cellular excitability patterns via precise phase  delays. Thus, understanding the circuit mechanisms underlying traveling waves is  essential to our understanding of how neural computations maintain millisecond timing.  Here, I will discuss ongoing work using microfabricated NeuroGrids combined with  simultaneous multiphoton imaging to map traveling wave dynamics and their underlying  circuit components. In mouse barrel cortex, we found that sensory input elicits distinct  feedforward and feedback traveling waves that can be modulated by reward  reinforcement. In particular, we link the feedback wave to two layer-specific circuit  motifs: enhanced L2/3 network sparsity and sharpened L5 calcium in the apical  dendrites. These results provide compelling evidence that traveling waves influence  sensory perception by sculpting local microcircuit activity and cortical outputs. 

Daniel Gonzales, Purdue University

Hosted by - Monique Mendes

About the BELONG Seminar Series

The BELONG seminar series features scientific talks from exceptional postdocs in the neurosciences who identify as Black, Indigenous, Latinx, and/or Person of Color. Sponsored by the Wu Tsai Neurosciences Institute Committee for Diversity, Inclusion, Belonging, Equity and Justice (DIBEJ).

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