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Functionally specific circuits in sensory and motor behaviors - Fan Wang

March 29, 2018 - 12:00pm to 1:00pm
Clark Center Auditorium

Functionally specific circuits in sensory and motor behaviors

Stanford Neurosciences Institute, Fan Wang

Fan Wang, Ph.D

Professor of Neurobiology and Cell Biology
Duke University Medical Center

Host: Nirao Shah



We developed a methodology called CANE for capturing activated neuronal ensembles. We applied the CANE technology to study motor cortical circuits involved in learning a skilled reaching and grasping task, midbrain circuits for controlling ultrasonic vocalization, as well as circuits for processing affective pain. In each case, neuronal ensembles specifically involved in the specific behaviors were identified in regions otherwise containing heterogenous populations of neurons serving diverse functions. We use a combination of in vivo imaging in freely behaving mice, electrophysiology and optogenetic manipulations during behaviors to reveal the causal functions of identified neuronal ensembles.

Speaker CV

[1] Sakurai, K., Zhao, S., Takatoh, J., Rodriguez, E., Lu, J., Leavitt, A., Han, B., Fu, M., and Wang, F.  Capturing and manipulating activated neuronal ensembles with CANE delineates a hypothalamic social fear circuit. (2016). Neuron. 92(4):739-753.  DOI:10.1016/j.neuron.2016.10.015 2/2Rodriguez_NN.pdf Rodriquez, E., Sakurai, K., Xu, J., Chen, Y., Toda, K., Zhao, S., Han, B., Ryu, D., Yin, H., Liedtke, W. and Wang, F. A craniofacial-specific monosynaptic circuit enables heightened affective pain. (2017). Nature Neuroscience, 20: 1734-1743. DOI:10.1038/s41593-017-0012-1

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Stanford Neurosciences Institute
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