Presenilins and Alzheimer's disease - Jie Shen

Event Details:

Thursday, September 24, 2015
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12:00pm to 1:00pm PDT
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Stanford Neurosciences Institute
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Stanford Neurosciences Institute Seminar Series Presents


Presenilins and Alzheimer’s disease: new insight into the pathogenic mechanism


Jie Shen, Ph.D.


Professor of Neurology, Harvard Medical School Center for Neurological Diseases

Host: Aaron Gitler


Presenilin constitutes the catalytic subunit of gamma-secretase and is the major genetic hotspot for familial Alzheimer’s disease, harboring ~90% of causative mutations. We employed gene targeting and multidisciplinary analysis in a series of mouse models to elucidate the normal functions of Presenilin and how these functions are perturbed by pathogenic mutations. I will present our unexpected findings and discuss their implications for understanding disease mechanisms and devising effective therapeutic strategies.

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Recent Papers

[1] Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer's Disease. Dan Xia, Hirotaka Watanabe, Jie Shen, Raymond Kelleher lll Neuron. 2015 Mar 4;85(5):967-81. doi:10.1016/j.neuron.2015.02.010

[2] Presenilins are essential for regulating neurotrasnmitter release. Chen Zhang, Bei Wu, Vassilios Beglopoulos, Mary Wines-Samuelson, Dawei Zhang, Ioannis Dragatsis, Thomas C. Südhof, Jei Shen Nature. 2009 May 27;460:632-36. doi:10.1038/nature08177

A conversation with Jie Shen and the Stanford group NeuWrite West can be streamed or downloaded: Shen Conversation

Lab Website