Join the speaker for coffee, cookies, and conversation before the talk, starting at 11:45am.
Enhancer AAVs for basic and translational applications
The brain is the most complex organ in the human body and is comprised of a diversity of cell types that execute a variety of functions. Recent advances in single cell profiling have enabled better definitions of cell types and provided a framework for their systematic characterization. Genetic tools to selectively access these specific cell populations and perturb them in different experimental contexts are critical to further our knowledge of brain function in healthy and diseased states. In this seminar, I will present our enhancer AAV technology platform (Graybuck, Daigle et al., Neuron 2021 and Mich et al., Cell Reports 2021) and share collections of off-the-shelf AAVs that can used in a flexible and cost-effective manner to target one or more cell types and/or brain regions across species, and that can be combined with existing transgenic mouse lines such as our TIGRE-based reporters (Daigle, Madisen et al., Cell 2018). I will discuss the potential of our enhancer AAVs for treating circuit-selective brain disorders, and discuss the various challenges of human gene therapy for CNS targets and with transforming a basic research tool into an effective clinical candidate.
Tanya Daigle, Ph.D.
Tanya Daigle is an Assistant Investigator in the Human Cell Types department at the Allen Institute for Brain Science. She holds a B.S. degree from U.C. San Diego and a Ph.D. degree in Physiology and Biophysics from the University of Washington in Seattle. She has held research positions at the Salk Institute for Biological Studies, Duke University and McGovern Institute for Brain Research at MIT. She is a molecular neuroscientist with expertise in the general areas of genetic tool development, neurodegenerative and addiction-related disorders, and human gene therapy.
Hosted by - Jacqueline Bendrick (Kaltschmidt Lab)
The Wu Tsai Neurosciences Institute seminar series brings together the Stanford neuroscience community to discuss cutting-edge, cross-disciplinary brain research, from biochemistry to behavior and beyond.
Topics include new discoveries in fundamental neurobiology; advances in human and translational neuroscience; insights from computational and theoretical neuroscience; and the development of novel research technologies and neuro-engineering breakthroughs.
Unless otherwise noted, seminars are held Thursdays at 12:00 noon PT.