Signal processing methods to interrogate multiple biomarkers of traumatic brain injury in one mPET imaging session

The underlying disease mechanisms of traumatic brain injury (TBI) and related conditions are not fully understood. Positron emission tomography (PET) has emerged as a promising tool for assessing neurological disease biomarkers. We aim to revolutionize the understanding of TBI by developing simultaneous multi-tracer or multiplexed PET (mPET), employing special radionuclides and novel signal processing methods. We will validate these methods through triple-tracer experiments in a preclinical scanner using mice and phantom experiments in a clinical scanner. By interrogating multiple TBI biomarkers through mPET, we will enable comprehensive molecular characterization and effective treatment for this complex disorder and beyond.