Anne Brunet

Anne Brunet

Professor, Genetics
Member, Bio-X
Member, Cardiovascular Institute
Member, Wu Tsai Human Performance Alliance
Member, Stanford Cancer Institute
Member, Wu Tsai Neurosciences Institute
B.Sc., Ecole Normale Superieure, Paris, Molecular Biology (1992)
Ph.D., University of Nice, France, Cell Biology (1997)
Postdoctoral fellow, Harvard Medical School, Neuroscience (2003)
Affiliation:
Affiliated Faculty
Committee:
Knight Initiative Steering Committee
Big Ideas in Neuroscience
Brunet Lab Home Page
Paul F. Glenn Laboratories for the Biology of Aging
Stanford Profile
Dr. Brunet is interested in the molecular mechanisms of aging and longevity, with a particular emphasis on the nervous system. Her lab is interested in identifying pathways involved in delaying aging in response to external stimuli such as availability of nutrients and mates. She also seeks to understand the mechanisms that influence the rejuvenation of old stem cells. Finally, her lab has pioneered the naturally short-lived African killifish as a new model to explore the regulation of aging and age-related diseases.

Related Projects

Wu Tsai Neurosciences Institute
Neuroscience:Translate Award
2021
Optimization of the African killifish platform for rapid drug screening for aggregate based neurodegenerative diseases
There are currently no available drugs for neurodegenerative diseases, including Alzheimer’s disease. Using the power of a new vertebrate aging model, the African killifish, this team is investigating age-dependent protein aggregation at a systems level and identifying aggregating proteins in the aging brain. There is huge potential to optimize the killifish platform for phenotypic screening of drug libraries, notably those targeted at protein aggregation, which is central to neurodegenerative diseases.
Knight Initiative for Brain Resilience
Brain Resilience Scholar Award
2023
Rejuvenating sleep to enhance brain resilience with age

Sleep is a critical behavioral state that fulfills essential needs for health, including clearing waste products (e.g., protein aggregates) from the brain. But sleep is not everlasting. As humans age, sleep quality strikingly deteriorates, and this decline is associated with dementias (e.g., Alzheimer’s disease).

Wu Tsai Neurosciences Institute
Interdisciplinary Scholar Award
2020
Reprogramming organismal lifespan through modulation of neuropeptidergic circuits

Aging is the number one risk factor for debilitating diseases such as neurodegeneration. Can manipulation of neurons in the brain alter the body’s physiological state to extend lifespan? Neuropeptides are key modulators of short-term homeostasis such as feeding, temperature, and sleep.

Related News

More News