John Huguenard

Constipation and diarrhea, caused by aberrant water absorption in the colon, impose substantial health burdens. The enteric nervous system (ENS) harbors a specialized circuit for water absorption, the secretomotor/vasodilator circuit, but its role in the proximal colon remains poorly understood.

Our goal is to develop the next generation of neural interfaces that match the resolution and performance of the biological circuitry. We will focus on two signature efforts to spearhead the necessary advances: high-density wire bundles for electrical recording and stimulation, and analog and digital bi-directional retinal prostheses for restoration of vision.