Sergiu P. Pasca

This study will introduce a vascular-like electronic system that merges seamlessly with neural organoids, establishing an integrated vascular-electronic-neural network. This envisaged platform holds the promise of heralding a transformative phase in the evolution of human neural organoid research and elucidating the fundamental understanding on the roles of oxygen and nutrient perfusion during neural development.

Developing brain organoids – three dimensional brain tissues grown in the lab – to study human brain development, evolution and neuropsychiatric disorders.

Electrodes implanted in the brain have great potential, with applications in neurodegenerative disease, brain-computer interfaces, and more. However, the presence of electrodes in brain tissue causes a response known as gliosis, in which a scar forms around the electrode, reducing its effectiveness and access to neurons.