Knight Initiative News

A study of killifish reveals how protein dysfunction develops in vertebrate brain cells, a key driver of aging – shedding light on cognitive decline and diseases like Alzheimer’s, Parkinson’s, and ALS.

Stanford researchers reviewed over 400 therapy evaluations and discovered a crucial mismatch: Mouse studies test disease prevention, while human trials test treatment of existing disease.

Knight Initiative researchers used a new lab model of aging human neurons to show that as cells age, lysosomes fall into disrepair and waste builds up—feeding a damaging cycle that could lead to Alzheimer’s.

Blood and cerebrospinal fluid markers tied to inflammation and metabolism sort some patients into subgroups, according to Knight Initiative researchers, a step toward predicting progression and tailoring care.

The technique, which used genetically healthy donor cells, prolonged life and function in mice with a disease similar to Tay-Sachs. It may help with other neurodegenerative diseases like Alzheimer’s.

The lab’s second crop of pilot awards will foster research in visual attention, the neurophysiology of exercise, and therapies for autism and mild cognitive impairment associated with aging.

Andreasson received the Inge Grundke-Iqbal Award for her work on restoring cognition in Alzheimer's. Karly Cody, a postdoctoral fellow in the lab of Knight Initiative researcher Elizabeth Mormino, was also honored.

Is your brain aging faster than your chronological age? New research shows it could raise your risk of death and dementia significantly—and offers promise for early intervention.

Knight Initiative-funded research ran the gamut from chemistry to public health, but one theme brought it all together: Studying what makes the brain resilient will help more people live better lives.

The findings of two recent studies give hope that the disease could one day be reversed in humans—but experts warn that this complex disease will likely need multiple complementary treatments.

A new Stanford study used blood proteins to analyze the 'biological' age of brains and other organs compared to the person's actual age.

The tool, built by a team led by Stanford's Tony Wyss-Coray, uses a single vial of blood to assess the 'biological age' of each organ.

A blood-test analysis developed at Stanford Medicine can determine the “biological ages” of 11 separate organ systems in individuals’ bodies and predict the health consequences.

Research in mice indicates that inhibiting the LRRK2 enzyme could stabilize patients with a type of Parkinson’s disease.

In which physician-scientist Marion Buckwalter shares the remarkable advances we've seen in stroke care in recent decades, thanks to long-standing national support for curiosity-driven research

A new study supported by the Knight Initiative for Brain Resilience reveals how Alzheimer's disease and attention shape our ability to remember.

Scientists in the lab of chemical engineer Monther Abu-Remaileh are uncovering the cellular functions that go awry in degenerative brain disorders and identifying therapies that could treat them.

In which anesthesiologist Martin Angst shares how studying the biology of recovery may reveal why some aging brains withstand stress while others quietly unravel.

Researchers supported by a Neuroscience:Translate grant from Wu Tsai Neuro have developed a new technology for removing blood clots that is more than twice as effective as current techniques.

A team at Stanford, supported by the Knight Initiative for Brain Resilience, is using the biology of recovery to uncover why some aging brains withstand stress while others quietly unravel.