Knight Initiative News

In a new study in rats, scientists used ultrasound-activated nanoparticles to deliver ketamine and anesthetics to precise targets in the brain.

Knight Initiative researchers used a new lab model of aging human neurons to show that as cells age, lysosomes fall into disrepair and waste builds up—feeding a damaging cycle that could lead to Alzheimer’s.

Stanford Medicine scientists have developed a brain-computer interface that “reads” thoughts from speech-impaired patients — but only on their command — potentially restoring rapid communication.

Blood and cerebrospinal fluid markers tied to inflammation and metabolism sort some patients into subgroups, according to Knight Initiative researchers, a step toward predicting progression and tailoring care.

The technique, which used genetically healthy donor cells, prolonged life and function in mice with a disease similar to Tay-Sachs. It may help with other neurodegenerative diseases like Alzheimer’s.

Stanford Medicine researchers discuss the brain’s ancient wiring and how its built-in reward-seeking system can be hijacked by addiction—as well as ways to prevent and treat it.

New tools that reveal how neuron-specific waves travel through the brains of mice in real time hold promise for understanding diseases such as epilepsy and Alzheimer’s, and open avenues for advances in neuroscience and AI.

The Global Neurodegeneration Proteomics Consortium gathered a trove of data on potential signs of neurological disease—and researchers including Knight Initiative director Tony Wyss-Coray are already using it to make new discoveries.

An interdisciplinary team of Wu Tsai Neuro scientists working on balls of human neurons called organoids wanted to scale up their efforts and take on important new questions. The solution was all around them.

A blood-test analysis developed at Stanford Medicine can determine the “biological ages” of 11 separate organ systems in individuals’ bodies and predict the health consequences.

Research in mice indicates that inhibiting the LRRK2 enzyme could stabilize patients with a type of Parkinson’s disease.

Former Wu Tsai Neuro Interdisciplinary Postdoctoral Scholar Sergey Stavisky helped lead an effort to translate brain signals into speech.

A new study supported by the Knight Initiative for Brain Resilience reveals how Alzheimer's disease and attention shape our ability to remember.

Research from the Giocomo lab finds that mice create neural maps of the location of rewards, distinct from the well-known hippocampal maps of an animal's location in space.

Researchers supported by a Neuroscience:Translate grant from Wu Tsai Neuro have developed a new technology for removing blood clots that is more than twice as effective as current techniques.

Scientists found that humans and mice share persistent brain-activity patterns in response to negative sensory inputs – offering insight into emotion and potential links to neuropsychiatric disorders.

Knight Initiative researchers discover a biomarker in spinal fluid that could help forecast Alzheimer’s progression and improve clinical trials.

Cancer treatment with a cell-based immunotherapy causes mild cognitive impairment, according to research by Wu Tsai Neuro affiliate Michelle Monje and colleagues. They also identified compounds that could treat it.

Improving cells’ ability to sort and recycle components—including cholesterol—could lead to therapies for a wide range of neurodegenerative conditions.

In a new study, researchers created an AI model of the mouse visual cortex that predicts neuronal responses to visual images.