Knight Initiative News

Developed by Stanford researchers, NeuroString is a hair-thin multichannel biosensor and stimulator with promising potential applications in drug delivery, nerve stimulation, smart fabrics, and more.

A new study finds links between two popular models of the disease—and the results could change how researchers think about treatment.

Small cell lung cancer often metastasizes to the brain. A Stanford Medicine-led study shows the cancer cells form synapses with neurons, and signaling across these synapses encourages tumor growth.

Knight Initiative researchers are uncovering the fine points of how our brains learn to move. In the long run, their findings could help devise better treatments for Parkinson's disease.

A study of killifish reveals how protein dysfunction develops in vertebrate brain cells, a key driver of aging – shedding light on cognitive decline and diseases like Alzheimer’s, Parkinson’s, and ALS.

Wu Tsai Neuro affiliate Guosong Hong and colleagues developed a new technique to observe neuron formation and firing in juvenile mice, potentially enhancing our understanding of neurodevelopmental disorders and enabling new interventions.

Stanford researchers reviewed over 400 therapy evaluations and discovered a crucial mismatch: Mouse studies test disease prevention, while human trials test treatment of existing disease.

In a new study in rats, scientists used ultrasound-activated nanoparticles to deliver ketamine and anesthetics to precise targets in the brain.

Knight Initiative researchers used a new lab model of aging human neurons to show that as cells age, lysosomes fall into disrepair and waste builds up—feeding a damaging cycle that could lead to Alzheimer’s.

Stanford Medicine scientists have developed a brain-computer interface that “reads” thoughts from speech-impaired patients — but only on their command — potentially restoring rapid communication.

Blood and cerebrospinal fluid markers tied to inflammation and metabolism sort some patients into subgroups, according to Knight Initiative researchers, a step toward predicting progression and tailoring care.

The technique, which used genetically healthy donor cells, prolonged life and function in mice with a disease similar to Tay-Sachs. It may help with other neurodegenerative diseases like Alzheimer’s.

Stanford Medicine researchers discuss the brain’s ancient wiring and how its built-in reward-seeking system can be hijacked by addiction—as well as ways to prevent and treat it.

New tools that reveal how neuron-specific waves travel through the brains of mice in real time hold promise for understanding diseases such as epilepsy and Alzheimer’s, and open avenues for advances in neuroscience and AI.

The Global Neurodegeneration Proteomics Consortium gathered a trove of data on potential signs of neurological disease—and researchers including Knight Initiative director Tony Wyss-Coray are already using it to make new discoveries.

An interdisciplinary team of Wu Tsai Neuro scientists working on balls of human neurons called organoids wanted to scale up their efforts and take on important new questions. The solution was all around them.

A blood-test analysis developed at Stanford Medicine can determine the “biological ages” of 11 separate organ systems in individuals’ bodies and predict the health consequences.

Research in mice indicates that inhibiting the LRRK2 enzyme could stabilize patients with a type of Parkinson’s disease.

Former Wu Tsai Neuro Interdisciplinary Postdoctoral Scholar Sergey Stavisky helped lead an effort to translate brain signals into speech.

A new study supported by the Knight Initiative for Brain Resilience reveals how Alzheimer's disease and attention shape our ability to remember.