Hosted by Richard Roth (Ding Lab)
Wu Tsai Neuro's weekly seminar series is being held virtually during the spring quarter. We hope to be able to bring the community together for in-person seminars again in the fall.
Community members interested in meeting with this week's speaker should contact host Richard Roth of the Ding Lab.
This seminar has been cancelled
Zayd M. Khaliq
NINDS Intramural Research Program
Dr. Khaliq received his B.A. in Physics from Dartmouth College and his Ph.D. in Neuroscience from Northwestern University in 2006. During his graduate work with Indira Raman, he studied the initiation and propagation of action potentials in cerebellar Purkinje neurons. During his postdoctoral fellowship with Bruce Bean at Harvard Medical School, he studied the ionic mechanisms of firing in dopamine-releasing neurons located in the ventral tegmental area (VTA) and substantia nigra. He joined NINDS as an Investigator in 2011. His laboratory is focused on the cellular and synaptic mechanisms underlying behaviorally relevant firing patterns within the midbrain dopamine system.
Inhibitory control of dopaminergic neurons – dendrites, soma and axons
Dopamine-releasing neurons located in the midbrain fire bursts of action potentials during reward behaviors but pause their activity in response to aversive stimuli. This lecture will discuss recent work examining the cellular level mechanisms of these behaviorally relevant firing patterns. Specifically, the lecture will discuss how synaptic inputs arriving from surrounding basal ganglia nuclei interact with the intrinsic firing properties of substantia nigra dopaminergic neuron to produce inhibitory pauses and rebound firing. The second part of the lecture will cover recent work examining GABAergic control of the axons of dopaminergic neurons. Dopaminergic axons transmit reinforcement signals to the striatum through patterns of propagating action potentials. Within the striatum, dopamine signals are shaped independently by input arriving from the local striatal circuit as well as by receptor-mediated conductances that directly influence axonal excitability and dopamine release. This lecture will discuss the mechanisms by which GABAergic receptors shape the subthreshold membrane potential of dopaminergic axons, propagated firing, and ultimately striatal dopamine release.