Deconstructing the neurobiology of addiction towards treatment interventions
Yasmin Hurd, PhD
Director, Addiction Insitute at Mount Sinai
Professor, Pharmacological Sciences, Neuroscience, and Psychiatry
Host: Xiaoke Chen
Drugs of abuse have taken center stage throughout the country as opioids have become a primary public health concern and previously illicit drugs such as cannabis have gained attention for medicinal purposes. The talk will provide insights about recent advances made in into the molecular neurobiological underpinnings of addiction disorders that provide avenues for the development of novel treatment interventions. A translational and multidisciplinary scientific approach will be described ranging from molecular and epigenetic studies in animal models to neurobiological investigations of the postmortem human brain that together guides human clinical studies.
 Michael L. Miller, Benjamin Chadwick, Dara L. Dickstein, Immanuel Purushothaman, Gabor Egervari, Tanni Rahman, Chloe Tessereau, Patrick R. Hof, Panos Roussos, Li Shen, Mark G. Baxter & Yasmin L. Hurd. Adolescent exposure to Δ9-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons. olecular Psychiatry (2018). DOI: 10.1038/s41380-018-0243-x
 Gabor Egervari, Joseph Landry, James Callens, John F. Fullard, Panos Roussos, Eva Keller, and Yasmin L. Hurd. Striatal H3K27 Acetylation Linked to Glutamatergic Gene Dysregulation in Human Heroin Abusers Holds Promise as Therapeutic Target. Biological Psychiatry, Volume 81, Issue 7, 1 April 2017, Pages 585-594. DOI: 10.1016/j.biopsych.2016.09.015