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Intrinsic plasticity and engram formation in neural circuits - Christian Hansel

January 11, 2018 - 12:00pm to 1:00pm
Clark Center Auditorium

Intrinsic plasticity and engram formation in neural circuits

Christian Hansel, PhD

Professor, Departmeent of Neurobiology, The University of Chicago, Chicago, IL

Host: Lu Chen


Synaptic plasticity (e.g. long-term potentiation; LTP) is considered the cellular correlate of learning. Recent optogenetic studies on memory engram formation assign a critical role in learning to suprathreshold activation of neurons and their integration into active engrams (“engram cells”). In this presentation, I will argue that ensemble integration may result from LTP, but also from cell-autonomous changes in membrane excitability. I propose that synaptic plasticity determines connectivity maps, whereas intrinsic plasticity — possibly separated in time — amplifies neuronal responsiveness and acutely drives engram integration. This proposal marks a move away from an exclusively synaptocentric toward a non-exclusive, neurocentric view of learning.

Curriculum Vitae

Related Papers

[1] Claire Piochon, Masanobu Kano & Christian Hansel (2016). LTD-like molecular pathways in developmental synaptic pruning. Nature Neuroscience 19, 1299–1310.  doi:10.1038/nn.4389

[2] Titley HK, Brunel N, Hansel C (2017). Toward a Neurocentric View of Learning. Neuron. 2017 Jul 5;95(1):19-32. doi: 10.1016/j.neuron.2017.05.021.

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Stanford Neurosciences Institute
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