Event Details:
Yukiko Goda, PhD
Team Leader, Synaptic Plasticity and Connectivity
RIKEN Center for Brain Science
Host: Lu Chen
Abstract
Synaptic strength and its use-dependent changes are crucial for how the brain perceives the environment, learns and stores memories. Yet, precisely how the strengths of individual synapses are set and controlled in relationship to other synapses sharing the connection, which in turn are crucial for specific behaviours, remain to be clarified. By combining electrophysiology, imaging, and molecular biology, we have studied the cellular rules that drive the activity-dependent spatial distribution of individual pre- and postsynaptic strengths across incoming axons onto a target neuron in hippocampal networks. Our recent findings highlighting asymmetric regulation of pre and postsynaptic strengths and ongoing work aimed at understanding a role for astrocytes in shaping the distribution of synaptic strengths will be presented.
Recent Papers
[1] Mathieu Letellier, Florian Levet, Olivier Thoumine, and Yukiko Goda. Differential role of pre- and postsynaptic neurons in the activity-dependent control of synaptic strengths across dendrites. PLoS Biol 17(6), June 5, 2019. doi: 10.1371/journal.pbio.2006223
[2] Mathieu Letellier, Yun Kyung Park, Thomas E. Chater, Peter H. Chipman, Sunita Ghimire Gautam, Tomoko Oshima-Takago, and Yukiko Goda. Astrocytes regulate heterogeneity of presynaptic strengths in hippocampal networks. PNAS, April 26, 2016. doi: 10.1073/pnas.1523717113