Shane Liddelow - Functional characterization of reactive astrocytes in inflammation and disease

Event Details:

Thursday, June 8, 2023
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12:00pm to 1:00pm PDT
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Wu Tsai Neurosciences Institute
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Join us at Gunn Rotunda in the Stanford Neurosciences Building to learn about the latest cutting-edge, cross-disciplinary brain research, from biochemistry to behavior and beyond

Wu Tsai Neuro's weekly seminar series is back to being held in-person since Fall 2022. Masking is strongly encouraged for the health and safety of our community Join the speaker for coffee, cookies, and conversation after the talk

Functional characterization of reactive astrocytes in inflammation and disease



Shane Liddelow

New York University

(Visit lab website)

Shane is an assistant professor in the Neuroscience Institute at NYU Grossman School of Medicine, with appointments in the Departments of Neuroscience & Physiology and Ophthalmology. In 2021 he was appointed as co-Director of the Parekh Center for Interdisciplinary Neurology and Grossman School of Medicine. His lab researches mechanisms that induce different forms of reactive astrocytes, and investigates how they interact with other cells in the central nervous system in a positive or negative way. He believes that the discovery of astrocytes with different reactive states has important implications for the development of new therapies for brain injury and diseases. Shane gained his Bachelors of Science (Hons) and Biomedical Science from the University of Melbourne, Australia, majoring in Neuroscience and Anatomy & Cell Biology. He received his PhD in Pharmacology also from the University of Melbourne working on the blood-brain barrier. As a postdoc in the lab of Ben Barres at Stanford University his research focused on astrocytes. His research showed that one form of reactive astrocyte is induced by factors released by microglia. These astrocytes, present in the brains of patients with several neurodegenerative diseases, release a toxic factor that kills certain neurons. Further investigation in his independent lab at NYU Grossman School of Medicine uncovered that toxic lipids produced by specific reactive astrocytes were responsible for this neuron cell death. His lab continues to uncover new sub-states of reactive astrocytes – producing novel models and tools to study their function and determine their role in infection and disease.

Hosted by - David Prince

About the Wu Tsai Neuro Seminar Series

The Wu Tsai Neurosciences Institute seminar series brings together the Stanford neuroscience community to discuss cutting-edge, cross-disciplinary brain research, from biochemistry to behavior and beyond.

Topics include new discoveries in fundamental neurobiology; advances in human and translational neuroscience; insights from computational and theoretical neuroscience; and the development of novel research technologies and neuro-engineering breakthroughs.

Unless otherwise noted, seminars are held Thursdays at 12:00 noon PT.

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