Signals and circuits for brainstem control of active sensing
David Kleinfeld, PhD
Chair and Distinguished Professor
UC San Diego
Host: John Huguenard
Brainstem function is necessary for life-sustaining functions, such as breathing, and for survival functions, such as foraging for food. Individual motor actions are activated by specific brainstem motor nuclei. The specificity of individual motor actions reflects the participation of pre2motor, premotor, and motor nuclei in circuits within closed loops between sensors and muscle actuators. I will discuss how different actions are coordinated to form a rich repertoire of behaviors, such as rhythmic motions linked to breathing, and the orchestrated displacements of the head, nose, tongue, and vibrissae during exploration. Further, to integrate connectivity data that arises from tracing studies, I describe an active texture-based atlas that utilizes machine learning to automatically achieve a precise alignment of neuronal projections across brains from different animals.
 Celine Mateo,Per M. Knutsen, Philbert S.Tsai, Andy Y.Shih, David Kleinfeld. Entrainment of Arteriole Vasomotor Fluctuations by Neural Activity Is a Basis of Blood-Oxygenation-Level-Dependent “Resting-State” Connectivity. Neuron, Volume 96, Issue 4, 15 November 2017, Pages 936-948.e3. DOI: 10.1016/j.neuron.2017.10.012
 Yuncong Chen, Lauren E. McElvain, Alexander S. Tolpygo, Daniel Ferrante, Beth Friedman, Partha P. Mitra, Harvey J. Karten, Yoav Freund, David Kleinfeld. An Active Texture-based Atlas for Automated Mapping of Structures and Markers Across Brains. UC San Diego. ProQuest ID: Chen_ucsd_0033D_17188. Merritt ID: ark:/13030/m5vm98m4. Retrieved from https://escholarship.org/uc/item/5zt9d974