Event Details:
Join us at Gunn Rotunda in the Stanford Neurosciences Building to learn about the latest cutting-edge, cross-disciplinary brain research, from biochemistry to behavior and beyond
Wu Tsai Neuro's weekly seminar series is back to being held in-person since Fall 2022. Masking is strongly encouraged for the health and safety of our community Join the speaker for coffee, cookies, and conversation after the talk
Microglial roles in brain physiology and pathology
Abstract
The brain is made up of a variety of cells with different functions. Long assumed to play insignificant roles in brain physiology and pathology, microglia, the brain-resident immune cells of the brain have now emerged as critical regulators of important brain functions in health and pathology. In this talk, Dr. Eyo will present work from his lab where they have identified the microglial-specific P2RY12 receptor in the control of brain function in various physiological and pathological conditions
Ukpong Eyo
University of Virginia
Dr. Eyo (pronounced “A”-“Yo”) was born in Nigeria and grew up in several different countries. He immigrated to the US in 2003 to pursue undergraduate studies at Northwest Missouri State University. He then went on to graduate school at the University of Iowa where he developed a keen interest in real-time imaging of microglia during development under the mentorship of Dr. Michael Dailey. During his time in the Dailey Lab, Eyo reported remarkable migratory capacities for neonatal microglia and elucidated purinergic mechanisms in microglial demise under simulated ischemic conditions. Following his Ph.D studies, Eyo joined the lab of Dr. Long-Jun Wu, first at Rutgers University in New Jersey, then at Mayo Clinic in Minnesota to study microglial-neuronal communications. His postdoctoral research in the Wu Lab uncovered novel physical interaction phenomena between microglia and neurons including microglial process extensions (Eyo et al., 2014), microglial process convergence (Eyo et al., 2015; Eyo et al., 2017) and microglial process pouches (Eyo et. al., 2021). Moreover, he showed that microglial neuronal communication was beneficial following experimentally-induced seizures. Through these studies, Dr. Eyo became interested in microglial P2RY12 receptors which he continues to study. Since August 2018, Eyo started his independent lab in the Department of Neuroscience and the Center for Brain Immunology and Glia (BIG) to continue his research on microglia in (i) neural injury (especially seizure disorders); (ii) neurovascular interactions and function and (iii) sex differences. Away from the lab, Dr. Eyo enjoys time with his blessed family including his wife, two sons, and two daughters.
Hosted by - Shan Jiang (Guosong Hong Lab)
About the Wu Tsai Neuro Seminar Series
The Wu Tsai Neurosciences Institute seminar series brings together the Stanford neuroscience community to discuss cutting-edge, cross-disciplinary brain research, from biochemistry to behavior and beyond.
Topics include new discoveries in fundamental neurobiology; advances in human and translational neuroscience; insights from computational and theoretical neuroscience; and the development of novel research technologies and neuro-engineering breakthroughs.
Unless otherwise noted, seminars are held Thursdays at 12:00 noon PT.