Knight Initiative News

The genetic variant APOE4, carried by one-fifth of the world’s people, substantially boosts Alzheimer’s risk. But scientists have been puzzled about how to reverse that risk: punch up the gene variant’s potency, or smack it down? Now we know, thanks to research funded by the Knight Initiative for Brain Resilience.

Researchers from around the university will collaborate to deepen our understanding of the brain.

Stanford's Office of Postdoctoral Affairs has named Hulya Torun one of this year's Postdoc Champions

A new study finds links between two popular models of the disease—and the results could change how researchers think about treatment.

Knight Initiative researchers are uncovering the fine points of how our brains learn to move. In the long run, their findings could help devise better treatments for Parkinson's disease.

Stanford undergrads and local community college students paired with Wu Tsai Neurosciences Institute researchers to find new ways to head off strokes, predict Alzheimer's disease, and more.

A study of killifish reveals how protein dysfunction develops in vertebrate brain cells, a key driver of aging – shedding light on cognitive decline and diseases like Alzheimer’s, Parkinson’s, and ALS.

Stanford researchers reviewed over 400 therapy evaluations and discovered a crucial mismatch: Mouse studies test disease prevention, while human trials test treatment of existing disease.

Knight Initiative researchers used a new lab model of aging human neurons to show that as cells age, lysosomes fall into disrepair and waste builds up—feeding a damaging cycle that could lead to Alzheimer’s.

Blood and cerebrospinal fluid markers tied to inflammation and metabolism sort some patients into subgroups, according to Knight Initiative researchers, a step toward predicting progression and tailoring care.

The technique, which used genetically healthy donor cells, prolonged life and function in mice with a disease similar to Tay-Sachs. It may help with other neurodegenerative diseases like Alzheimer’s.

The lab’s second crop of pilot awards will foster research in visual attention, the neurophysiology of exercise, and therapies for autism and mild cognitive impairment associated with aging.

Andreasson received the Inge Grundke-Iqbal Award for her work on restoring cognition in Alzheimer's. Karly Cody, a postdoctoral fellow in the lab of Knight Initiative researcher Elizabeth Mormino, was also honored.

Is your brain aging faster than your chronological age? New research shows it could raise your risk of death and dementia significantly—and offers promise for early intervention.

Knight Initiative-funded research ran the gamut from chemistry to public health, but one theme brought it all together: Studying what makes the brain resilient will help more people live better lives.

The findings of two recent studies give hope that the disease could one day be reversed in humans—but experts warn that this complex disease will likely need multiple complementary treatments.

A new Stanford study used blood proteins to analyze the 'biological' age of brains and other organs compared to the person's actual age.

The tool, built by a team led by Stanford's Tony Wyss-Coray, uses a single vial of blood to assess the 'biological age' of each organ.

A blood-test analysis developed at Stanford Medicine can determine the “biological ages” of 11 separate organ systems in individuals’ bodies and predict the health consequences.

Research in mice indicates that inhibiting the LRRK2 enzyme could stabilize patients with a type of Parkinson’s disease.