Mable Lam

Wu Tsai Neurosciences Institute
Postdoctoral Research Fellow
Department of Neurosurgery

Mable is studying the mechanisms of myelination as a postdoctoral fellow in laboratory of Dr. Brad Zuchero. She graduated from Amherst College as a Chemistry major and received her Ph.D. in Biochemistry from the University of California, San Francisco (UCSF). At UCSF, Mable worked in the laboratory of Dr. Peter Walter to investigate how cells succumb to apoptosis during protein misfolding stress in the secretory pathway. Many cell types of the central nervous system (CNS), including oligodendrocytes that generate myelin, must expand and upregulate the capacity of its secretory pathway during differentiation. Mable is collaborating with the laboratory of Dr. Michael Bassik to apply a comprehensive genetic approach towards identifying essential pathways for generating myelin. Uncovering these pathways will provide new therapeutic avenues for demyelinating diseases and expand our current understanding of how cell morphology is regulated in the CNS.