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Dissecting hippocampal circuits operations for navigation and learning - Attila Losonczy

November 30, 2017 - 11:00am to 12:00pm
Clark Center Auditorium

Dissecting hippocampal circuits operations for navigation and learning

Attila Losonczy, MD, PhD

Associate Professor, Department of Neuroscience, Columbia University, New York

Host: Matthew Lovett-Barron (Deisseroth Lab)


Learning and remembering where and when salient events occur in space and time are essential for adaptive behaviors. Both spatial navigation and episodic memory have been linked to the mammalian hippocampus, but the detailed mechanisms at cellular and circuit levels remain poorly understood. To address these questions, we use in vivo functional imaging to monitor the activity of identified excitatory, inhibitory and neuromodulatory circuit motifs in the hippocampus of behaving mice during spatial exploration, fear learning and goal-directed learning. The talk will focus on our recent efforts aimed at dissecting functional roles of multimodal microcircuits at the dentate gyrus input and at the CA1 output nodes of the hippocampus. I will summarize how various types of dentate gyrus principal neurons – adult-born and mature granule cells, and hilar mossy cells contribute to context encoding and discrimination. We also monitored activity in deep and superficial subpopulations of CA1 pyramidal cells, and assessed the relationship between sublayer dynamics and learning.  Finally, I will present findings on how goal-oriented learning is supported by disinhibitory GABAergic circuits in CA1. Together, our results demonstrate a functional division of labor among subpopulations of principal neurons during hippocampal-dependent behaviors.

Curriculum Vitae

Related papers

[1] JD Zaremba1,6 , A Diamantopoulou2,3,6, NB Danielson1 , AD Grosmark1, PW Kaifosh1,4, JC Bowler1, ZLiao1, FT Sparks1, JA Gogos1,3 & A Losonczy1,5. Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion. Nature Neuroscience 20, 1612–1623 (2017) doi:10.1038/nn.4634

[2] NB Danielson12, JD Zaremba12, P Kaifosh12, J Bowler12, M Ladow1, A Losonczy134. Sublayer-Specific Coding Dynamics during Spatial Navigation and Learning in Hippocampal Area CA1. Neuron Volume 91, Issue 3, 3 August 2016, Pages 652-665. doi: 10.1016/j.neuron.2016.06.020


Event Sponsor: 
Stanford Neurosciences Institute
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