Big Ideas in Neuroscience

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Cross-disciplinary teams transforming our understanding of the brain

Big Ideas are the Wu Tsai Neurosciences Institute's flagship research projects. These three-year grants catalyze cross-disciplinary teams of researchers to collaboratively tackle fundamental questions that advance our understanding of the mind, brain and behavior in health and disease.


Our Big Ideas projects include bold projects to advance our understanding of the science of addiction and brain rejuvenation, to design new technologies to interface with the brain, and to build research platforms to connect molecular to systems-level neuroscience and advance the study of human brain organoids and assembloids in the lab.

Application and eligibility details can be found here.
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Apply for Big Ideas Grants

The deadline to submit a Letter of Intent for the Big Ideas program is January 13, 2025, 5:00 pm PT. 

Funded Big Ideas projects

Wu Tsai Neurosciences Institute
Big Ideas in Neuroscience Award
2015
NeuroChoice: Optimizing Choice - from neuroscience to public policy
This proposal brings together faculty from diverse disciplines to deepen our understanding of the neural mechanisms supporting choice, and extend this knowledge to optimize choices related to addiction and investment. This consilience will require new conceptual and experimental tools designed to bridge historically distant fields of inquiry. Our team aims to transform the scientific understanding of choice, and to translate relevant knowledge to promote more optimal decision-making.
Wu Tsai Neurosciences Institute
Big Ideas in Neuroscience Award
2018
Neuro-omics Initiative (Phase 1)

Creating new tools to help neuroscientists bridge the study of genes and proteins operating in the brain to the study of brain circuits and systems, which could lead to a deeper understanding of brain function and disease.

Wu Tsai Neurosciences Institute
Big Ideas in Neuroscience Award
2017
Stanford Brain Rejuvenation Project (Phase 2)

The Stanford Brain Rejuvenation Project is an initiative by leading aging researchers, neuroscientists, chemists, and engineers to understand the basis of brain aging and rejuvenation and how they relate to neurodegeneration.

Wu Tsai Neurosciences Institute
Big Ideas in Neuroscience Award
2015
Stroke Collaborative Action Network

Breaches barriers in our understanding of stroke to develop therapies and improve stroke recovery.

Wu Tsai Neurosciences Institute
Big Ideas in Neuroscience Award
2018
Stanford Brain Organogenesis Program (Phase 1)

Developing brain organoids – three dimensional brain tissues grown in the lab – to study human brain development, evolution and neuropsychiatric disorders.

Wu Tsai Neurosciences Institute
Big Ideas in Neuroscience Award
2017
Stanford NeuroTechnology Initiative (Phase 2)

Our goal is to develop the next generation of neural interfaces that match the resolution and performance of the biological circuitry. We will focus on two signature efforts to spearhead the necessary advances: high-density wire bundles for electrical recording and stimulation, and analog and digital bi-directional retinal prostheses for restoration of vision.

Wu Tsai Neurosciences Institute
Big Ideas in Neuroscience Award
2018
Neurodevelopment Initiative

Investigating how the brain develops from infancy to adulthood across species, focusing on how the interplay between structural development, functional development, experience and affect brain computations and ultimately behavior.