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Predicting and promoting resilient brain aging trajectories

Catalyst Awards | 2022
Funding Program: Catalyst and Momentum Awards

Using new animal models such as the African killifish, this team aims to develop approaches to predict individual brain aging trajectories early in life based on behaviors that can be modulated to promote healthy memory, executive function, and processing speed as well as to counter dementia.

Funded Researcher(s)

Anne Brunet
Karl Deisseroth
Scott W Linderman
Daniel Jarosz

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An African killifish swimming.
Press coverage |
Mar 18 2026
BBC Science Focus

Just one day in your life could soon reveal how long you'll live

After building a Truman Show experiment, scientists were able to predict the lifespans of their 81 subjects
Image
Anne Brunet presents to a large audience at the Wu Tsai Neurosciences Institute's 10th Annual Neurosciences Symposium. Photo by Ola Hopper.
News Features |
Mar 18 2026
Stanford Report

Can science slow down aging?

Wu Tsai Neuro affiliate Anne Brunet explores what aging really is, how lifestyle choices might influence longevity, and the promising frontiers of aging research
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Ravi Nath and Claire Bedbrook stand in an aisle of shelves filled with fish tanks.
Research news |
Mar 12 2026
Knight Initiative for Brain Resilience

Watching a lifetime in motion reveals the architecture of aging

Knight Initiative scientists tracked every moment of the life of the African turquoise killifish, showing that behavior alone can forecast whether an animal will live a long or short life
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Wu Tsai Neurosciences Institute

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