Funded Research Projects
NeuroDiscovery | Postdoctoral Fellowship
Lead Researcher(s): Matt McCoy
Many of the largest, most complex genes in the genome are enriched in the brain and are frequently mutated or misregulated in neurological diseases and disorders such as Alzheimer's disease, autism spectrum disorders, and Rett syndrome. This proposal outlines a detailed study of this distinct class...
NeuroHealth | Postdoctoral Fellowship
Lead Researcher(s): Caitlyn Seim
Vibrotactile stimulation provides powerful somatosensory and proprioceptive input to the nervous system. There is growing evidence that this stimulation may significantly improve limb function after brain injury. However, current technology restricts further research to short, laboratory studies...
NeuroHealth | SIGF - Graduate Fellowship
Lead Researcher(s): Kathryn Wu
Schwann cells (SCs) sort and myelinate peripheral axons, and impairments in either process can cause long-term disability. There are no therapeutic strategies for targeting SC dysfunction, underscoring the need to investigate mechanisms of sorting and myelination. Both processes require highly...
NeuroHealth | SIGF - Graduate Fellowship
Lead Researcher(s): Gustavo Chau
Absence epilepsy is a form of pediatric epilepsy which causes seizures with brief lapses in awareness. Electron microscopy results in a murine model of absence epilepsy support the hypothesis that maladaptive myelination plays a role in disease progression. To enable whole-brain, longitudinal...
NeuroHealth | Neuroscience:Translate
Lead Researcher(s): Christopher Lee-Messer, MD, PhD, Daniel Rubin
Current automated seizure detection software is slow, inaccurate and rarely precise enough for clinicians to rely upon. This project aims to use cutting-edge AI methods to develop a powerful new algorithm that will enable better seizure diagnosis and treatment plan formation.
NeuroHealth | Neuroscience:Translate
Lead Researcher(s): Sean Mackey, M.D., Ph.D., Mark J. Schnitzer
In light of the dual public health crises of chronic pain and opioids, there is an urgent need to develop non-addictive alternative therapies for chronic pain. This project's goal is to develop a new protocol for transcranial magnetic stimulation — a non-invasive method of neuromodulation — that is...
NeuroEngineering | Neuroscience:Translate
Lead Researcher(s): Allison Okamura, Maarten Lansberg, MD, PhD
This team is developing wearable stimulation devices to improve limb function after stroke. The technology includes a tactile stimulation method, and the wireless, lightweight, and low-cost wearable computing devices to apply this stimulation.
NeuroHealth | Neuroscience:Translate
Lead Researcher(s): Eric Kool, Katrin Andreasson
Acute brain inflammation after stroke and head trauma causes adverse health outcomes affecting millions of patients each year in the U.S., and current treatments are insufficient. This project will test a promising new therapy to reduce inflammation by targeting the enzyme OGG1, a potentially...
NeuroEngineering | Neuroscience:Translate
Recurrent dizziness attacks are a debilitating condition for 10% of the population during their lifetime, and can lead to a complete inability to function, and to multiple hospital admissions and investigations chasing many potential diagnoses. This project aims to address the unmet need for means...
NeuroEngineering | Postdoctoral Fellowship
Lead Researcher(s): Alex Williams
Neural circuits can exhibit remarkable stability (e.g., when supporting long-term memory) as well as flexibility (e.g., when supporting rapid learning). While neuroscientists have begun to individually characterize these two aspects of neural computation, developing more complete scientific...
