Browse wide-ranging research at the frontiers of neuroscience supported by Wu Tsai Neurosciences Institute grants, awards, and training fellowships.
Projects
Massively parallel microwire arrays for deep brain stimulation
Brain mechanisms of spatial reasoning in mathematics
Creating an advanced transgenic animal model of autism
Autism is a highly genetic developmental brain disorder which is characterized by social impairments. Autism affects 1 in 68 US children, with an annual cost in the US of $250 billion dollars. Unfortunately, the basic biology of autism remains poorly understood.
Identification of sex hormone interacting proteins
Enabling faster and more responsive voltage imaging through computational biophysics
TrkA-ing the chronic pain
Remote and localized neural activation using sonomagnetic stimulation
Ultrasonic neural control and neuroimaging in the awake, mobile, and behaving small rodent
We propose to design a lightweight, wearable system for integrated ultrasonic drug uncaging and fUS neuroimaging to noninvasively pharmacologically modulate a brain target and then image the resultant changes in neural activity without significant motion limitations.
Genetic tools to determine circuit-specific roles of myelination
These tools will enable us to dissect how myelin contributes to specific brain circuits and types of neurons, bringing us closer to a holistic understanding of how cells in the brain collaborate to build a functional nervous system.
Injectable photovoltaics for a wireless, gliosis-free neural stimulation interface
We believe our research has the potential of generating transformative results for both neuroscience research and neurological applications, also offering strategies to manipulate key intracellular pathways to prevent gliosis in therapeutic neural implants.
Rapid brain-wide optogenetic screening with a noninvasive, dynamically programmable in vivo light source
Elucidating the biophysical mechanisms of latrophilin activation in excitatory synapse formation
Magnetic Recording and Stimulation of Neural Tissue
We propose a new magnetic sensor that is sensitive to picoTesla-scale fields, a localized magnetic stimulator with small form-factor, and a seamless integration of both systems for applications in experimental and clinical neuroscience.