Browse wide-ranging research at the frontiers of neuroscience supported by Wu Tsai Neurosciences Institute grants, awards, and training fellowships.
Projects
Tracking Parkinson’s Disease with transformer models of everyday looking behaviors
It is more common nowadays for people to have their own wearable devices to measure physiological signals like heart rate and respiration to keep track of physical diseases. However, monitoring decline in cognitive functions or development of neurodegenerative diseases, such as Parkinson’s (PD), is still complex and tricky.
Microglia-Mediated Astrocyte Activation in Chronic Pain
While acute pain is an important biological signal in response to injured tissue, chronic pain occurs when the pain signaling outlasts the initial injury and has deleterious effects on health and quality of life. Chronic pain represents an enormous public health burden with few therapeutic options.
Structural and mechanistic analysis of the protein-protein interface between ABCA1 and ApoE as a potential therapeutic target for Alzheimer’s Disease
We propose a new line of research whose goal is to examine the druggability of a protein-protein interface involving ApoE, an apolipoprotein whose gene variants represent the strongest genetic risk factor for AD.
Dissecting mechanisms of gut-brain communication in Parkinson’s Disease
People with Parkinson’s Disease (PD) have different types of bacteria in their guts compared to people without neurological diseases. We will study which gut bacteria for people with PD to gain a better understanding of how gut bacteria contribute to inflammation in the body and in the brain or people with this condition.
Novel ketone-derived anticonvulsant agents for the treatment of childhood refractory epilepsy
We propose to apply mass spectrometry techniques to measure BHB-Phe and other KD metabolites in children undergoing KD for refractory epilepsy at Stanford. Further, in a mouse model of refractory genetic epilepsy, we will compare targeted BHB-Phe treatment to full KD treatment using transcriptomics, EEG assessment of seizures and cognitive testing.
Life-long, minimally invasive, and multiplex transcriptional profiling of the cerebellum
Why do all our brains mature and age in different ways, leading to different cognitive and behavioral outcomes? We envision a novel method that “copies” the information from the RNAs made by the neurons to sensor RNAs we artificially introduce into live animals.
Use of gut-brain electrophysiology to study interoception in eating disorders
In this study, we aim to (i) perform a feasibility study to determine the acceptance and feasibility of performing such recordings in the AN and ARFID eating disorders population and (ii) test the hypothesis that the electrophysiologic monitoring of the brain and stomach is associated with a clinically validated behavioral measure of interoception involving water distention of the stomach.
In vivo selection for gene mutations that counteract photoreceptor degeneration
Developing a dopamine and neural systems model of anhedonia
More than 60 million people in the United States currently suffer from a serious mental illness, and the associated financial, productivity and human suffering costs are only projected to rise in the near future.
Cognitive remediation of distraction to reduce striatal dysregulation and improve clinical outcomes for individuals with psychosis
The ability to ignore distracters is impaired for individuals with psychosis. This impairment negatively impacts treatment effectiveness and the ability of individuals with psychosis to function fully.
Simultaneous 15O-PET and MRI of cerebral blood flow and cerebrovascular reserve
Continuous blood flow to the brain is needed for neural tissues to survive. Noninvasive imaging of cerebral blood flow (CBF) in humans is challenging, but is critically useful to understand normal brain physiology and to help patients with cerebrovascular disorders such as stroke.
Determining the microstructural basis of diffusion MRI
The aim of this project is to improve the accuracy and reliability of dMRI fiber tracking through comparison with a gold standard that unambiguously relates the measured water diffusion patterns to the underlying tissue structure.
A novel PET radioligand to identify microglial inflammation in Alzheimer's disease
A novel sigma-1 receptor PET radioligand as a probe of ketamine’s rapid therapeutic action in disorders of human brain and behavior: Pilot study
The impact of early medial temporal lobe Tau in human cognitive aging
Sustained release of growth factors from bioengineered synthetic "cells" for treating spinal cord injury
Spinal cord injury (SCI) is a debilitating condition that affects young adults between the ages of 16 and 30, which leads to lifelong medical and financial burdens. SCI still results in a decreased quality-of-life and lower life expectancy for patients. This is due in part to the lack of a regenerative-based therapeutic approach to treating SCI in the clinic.
Sensory processing in a pre-seizure state
Investigating the role of a human-specific repeat element in neuropsychiatric disease risk and cerebellar function
Quantifying auditory-vocal affect in human social communication
This proposal brings together faculty with this diverse expertise to develop the first gold standard test of auditory-vocal affect. Once developed, validated, and normed, we will deploy this test in the clinical context of autism to quantify impairments and direct neurobiological investigation.
Reprogramming organismal lifespan through modulation of neuropeptidergic circuits
Aging is the number one risk factor for debilitating diseases such as neurodegeneration. Can manipulation of neurons in the brain alter the body’s physiological state to extend lifespan? Neuropeptides are key modulators of short-term homeostasis such as feeding, temperature, and sleep.
Wearable stimulation for sensorimotor rehabilitation
Vibrotactile stimulation provides powerful somatosensory and proprioceptive input to the nervous system.
Mechanisms of myelin membrane expansion
Myelin is the protective covering that surrounds nerve fibers to accelerate communication between different parts of the nervous system. Damage to myelin occurs in diseases such as multiple sclerosis, which compromises nerve signaling and impairs motor and cognitive function.
Mapping the Mitophagy Network in Parkinson’s Disease
We will comprehensively define the gene network associated with mitochondrial dysfunction in Parkinson's disease using a cutting-edge technology, CRISPR, to understand how these nerve cells die in PD and how we can reverse the cell death to treat the disease.
Inflammation, Major Histocompatibility Class I and human brain development
Maternal infection is linked to increased risk of neurodevelopmental disorders such as autism and schizophrenia. This proposal examines how virus-associated cytokines, specifically interferons, affect human neurons modeled in brain organoids or studied directly in fetal brain samples.